Triethyl orthoacetate → HCID 178432094, compound

HRID 904644Notes

Reaction equation

HRID 904644 reaction equation
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([NH:6][C:7]1[NH:11][N:10]=[N:9][N:8]=1)=[O:5].[CH2:16](OC(OCC)(OCC)C)[CH3:17]>C(O)C>[CH3:16][C:17]1[N:6]([C:7]2[NH:11][N:10]=[N:9][N:8]=2)[C:4](=[O:5])[C:3]2[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:1]=1

Participants

4

Reactant 2

HCID 66221Triethyl orthoacetateHCID 178507500HCID 178507500, compound

Product 1

HCID 178432094HCID 178432094, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3.8 g of 2-amino-N-(1H-tetrazol-5-yl)benzamide and 3.3 g of 1,1,1-triethoxyethane in 50 ml of ethanol was heated at reflux for 18 hours. The mixture was then concentrated to a small volume and the resulting solid was collected by filtration and air dried to give 2-methyl-3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone melting at about 225°-226° C. This compound has the following structural formula: ##STR5##

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 18 hours
  3. concentrationThe mixture was then concentrated to a small volume
  4. filtrationthe resulting solid was collected by filtration and air
  5. customdried

Sources & evidence

ORD record
ord-357e0a6cd277414f9783c1887364d373
Source dataset
uspto-grants-1983_12
Patent number
US04419357

Reaction notes

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