Ethyl orthopropionate → 4(1H)-Quinazolinone

Participants

Reaction Steps

A slurry of 7.0 g of 2-amino-5-methyl-N-(1H-tetrazol-5-yl)benzamide and 5.7 g of 1,1,1-triethoxypropane in 50 ml of 2-methoxyethanol was heated at reflux for 48 hours. The solution was cooled and concentrated to a small volume. The resulting solid was then collected and air dried to give 2-ethyl-6-methyl-3-(1H)-tetrazol-5-yl)-4(3H)-quinazolinone melting at about 204°-205° C., after recrystallization from a mixture of dimethylformamide and water.

Provenance & Evidence