Sodium Hydroxide → HCID 13543945, compound

Participants

Reaction Steps

0.1 N Sodium hydroxide (28.9 mls) was added dropwise to the diester product of step (e) (0.646 g) in refluxing methanol (100 mls) with stirring, over 15 minutes. The reaction mixture was refluxed and stirred for a further 3 hours and the solution filtered and evaporated. The residue was dissolved in water (100 mls) and acidified. The precipitated acid was collected by filtration, washed with water and dried to give 0.4 g of the desired product. A recrystallisation from ethyl acetate gave 0.24 g, mp 204° (dec).

Provenance & Evidence