Sodium Hydroxide → HCID 13543948, compound

HRID 904677Notes

Reaction equation

HRID 904677 reaction equation
[OH-].[Na+:2].[Cl:3][C:4]1[C:13]2[C:8](=[C:9]([CH2:24][CH:25]=[CH2:26])[C:10]3[O:17][C:16]([C:18]([O:20]CC)=[O:19])=[CH:15][C:14](=[O:23])[C:11]=3[CH:12]=2)[N:7]=[C:6]([C:27]([O:29]C)=[O:28])[CH:5]=1>CO>[Cl:3][C:4]1[C:13]2[C:8](=[C:9]([CH2:24][CH:25]=[CH2:26])[C:10]3[O:17][C:16]([C:18]([O-:20])=[O:19])=[CH:15][C:14](=[O:23])[C:11]=3[CH:12]=2)[N:7]=[C:6]([C:27]([O-:29])=[O:28])[CH:5]=1.[Na+:2].[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20478435HCID 20478435, compound

Product 1

HCID 13543948HCID 13543948, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.1 m sodium hydroxide solution (24.9 ml) was added dropwise to the product of step (d) (0.5 grams) in refluxing pure methanol (100 ml), with stirring. The whole was refluxed for a further 10 minutes after addition, the methanol was removed under reduced pressure and the title compound obtained by precipitation by the addition of acetone. The product was collected by filtration and dried in vacuo at 60° C. to give 0.37 grams of dark yellow solid.

Workup

  1. temperatureThe whole was refluxed for a further 10 minutes
  2. additionafter addition
  3. customthe methanol was removed under reduced pressure

Sources & evidence

ORD record
ord-03de5407526140c8bb062bf2273b2eba
Source dataset
uspto-grants-1983_12
Patent number
US04419352

Reaction notes

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