1,3-Diethyl 2-oxopropanedioate → HCID 178438343, compound

HRID 904682Notes

Reaction equation

HRID 904682 reaction equation
[NH2:1][C:2]1[C:3]([NH2:20])=[C:4]([CH2:17][CH2:18][CH3:19])[C:5]2[O:10][C:9]([C:11]([O:13][CH3:14])=[O:12])=[CH:8][C:7](=[O:15])[C:6]=2[CH:16]=1.O=[C:22]([C:28](OCC)=[O:29])[C:23]([O:25][CH2:26][CH3:27])=[O:24]>C(O)C>[OH:29][C:28]1[C:22]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[N:20][C:3]2[C:4]([CH2:17][CH2:18][CH3:19])=[C:5]3[O:10][C:9]([C:11]([O:13][CH3:14])=[O:12])=[CH:8][C:7](=[O:15])[C:6]3=[CH:16][C:2]=2[N:1]=1

Participants

4

Reactant 2

HCID 691051,3-Diethyl 2-oxopropanedioateHCID 20478446HCID 20478446, compound

Product 1

HCID 178438343HCID 178438343, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product of step (c) above (0.6 g) was suspended in ethanol (25 ml), and diethyl ketomalonate (0.382 g) was added. The mixture was refluxed for 18 hours, and the resulting precipitate was collected (0.29 g) and identified as the sub-title compound by NMR and MS: δDMSO : 1.0 (3H,t), 1.4 (3H, t), 1.6 (2H, m), 3.0 (2H, t), 4.0 (3H, s), 4.4 (2H, q), 6.95 (1H, s), 8.2 (1H, s).

Workup

  1. temperatureThe mixture was refluxed for 18 hours
  2. customthe resulting precipitate was collected (0.29 g)

Sources & evidence

ORD record
ord-505fd5af64e64e7791434eef9132ac25
Source dataset
uspto-grants-1983_12
Patent number
US04419352

Reaction notes

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