反应详情

Methyl 6-acetyl-4-ethylthio-7-hydroxy-8-propylquinoline-2-carboxylate (1.0 g), was added to Raney Nickel (16 g wet wt; previously washed with ethanol) in dry ethanol (100 mls), and reflux for 11/2 hours. The catalyst was filtered off, and the filtrate evaporated to dryness. The residue was triturated with 40°-60° petroleum ether and the yellow solid collected by filtration to give 0.6 g of the sub-title product. A recrystallisation from ethanol gave 0.2 g, mp 110°-111°.

1. washpreviously washed with ethanol) in dry ethanol (100 mls)
2. temperaturereflux for 11/2 hours
3. filtrationThe catalyst was filtered off
4. customthe filtrate evaporated to dryness
5. customThe residue was triturated with 40°-60° petroleum ether
6. filtrationthe yellow solid collected by filtration