反应详情

The product of step (b) (1.118 g) was suspended in methanol (100 mls) and heated and stirred under reflux with the dropwise addition of N/10 sodium hydroxide solution (58.37 mls). The reaction mixture was stirred and heated under reflux for a further 15 mins, cooled, filtered and acidified. The precipitated product was collected by filtration, washed with water and dried to give 0.852 g, mp 252° dec.

1. temperatureheated
2. stirringThe reaction mixture was stirred
3. temperatureheated
4. temperatureunder reflux for a further 15 mins
5. temperaturecooled
6. filtrationfiltered
7. filtrationThe precipitated product was collected by filtration
8. washwashed with water
9. customdried
10. customto give 0.852 g, mp 252° dec.