Sodium Hydroxide → HCID 13543942, compound

HRID 904688Notes

Reaction equation

HRID 904688 reaction equation
[O:1]=[C:2]1[C:7]2[CH:8]=[C:9]3[C:14](=[C:15]([CH2:16][CH2:17][CH3:18])[C:6]=2[O:5][C:4]([C:24]([O:26]CC)=[O:25])=[CH:3]1)[N:13]=[C:12]([C:19]([O:21]CC)=[O:20])[CH:11]=[CH:10]3.[OH-].[Na+]>CO>[O:1]=[C:2]1[C:7]2[CH:8]=[C:9]3[C:14](=[C:15]([CH2:16][CH2:17][CH3:18])[C:6]=2[O:5][C:4]([C:24]([OH:26])=[O:25])=[CH:3]1)[N:13]=[C:12]([C:19]([OH:21])=[O:20])[CH:11]=[CH:10]3

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13543995HCID 13543995, compound

Product 1

HCID 13543942HCID 13543942, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product of step (b) (1.118 g) was suspended in methanol (100 mls) and heated and stirred under reflux with the dropwise addition of N/10 sodium hydroxide solution (58.37 mls). The reaction mixture was stirred and heated under reflux for a further 15 mins, cooled, filtered and acidified. The precipitated product was collected by filtration, washed with water and dried to give 0.852 g, mp 252° dec.

Workup

  1. temperatureheated
  2. stirringThe reaction mixture was stirred
  3. temperatureheated
  4. temperatureunder reflux for a further 15 mins
  5. temperaturecooled
  6. filtrationfiltered
  7. filtrationThe precipitated product was collected by filtration
  8. washwashed with water
  9. customdried
  10. customto give 0.852 g, mp 252° dec.

Sources & evidence

ORD record
ord-913ed98eea6e48a5a90330a29d1e0902
Source dataset
uspto-grants-1983_12
Patent number
US04419352

Reaction notes

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