Sodium Hydroxide → HCID 13543956, compound

HRID 904691Notes

Reaction equation

HRID 904691 reaction equation
[O:1]=[C:2]1[C:7]2[CH:8]=[C:9]3[C:14](=[C:15]([CH2:16][CH2:17][CH3:18])[C:6]=2[O:5][C:4]([C:31]([O:33]CC)=[O:32])=[CH:3]1)[N:13]=[C:12]([C:19]([O:21]CC)=[O:20])[CH:11]=[C:10]3[O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[OH-].[Na+:37]>CO>[O:1]=[C:2]1[C:7]2[CH:8]=[C:9]3[C:14](=[C:15]([CH2:16][CH2:17][CH3:18])[C:6]=2[O:5][C:4]([C:31]([O-:33])=[O:32])=[CH:3]1)[N:13]=[C:12]([C:19]([O-:21])=[O:20])[CH:11]=[C:10]3[O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[Na+:37].[Na+:37]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13543932HCID 13543932, compound

Product 1

HCID 13543956HCID 13543956, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product of step (b) (0.4162 g) was stirred in methanol (50 cm3) under reflux and was treated with 0.1 N sodium hydroxide solution (17.5 cm3), dropwise. The whole was stirred and refluxed for 15 minutes after addition, cooled, filtered and the filtrate evaporated to dryness. Water (30 cm3) was added and the solution was treated with acetone until complete precipitation was attained. The product was collected by filtration and dried to give 0.22 g of the title compound.

Workup

  1. temperatureunder reflux
  2. temperaturerefluxed for 15 minutes
  3. additionafter addition
  4. temperaturecooled
  5. filtrationfiltered
  6. customthe filtrate evaporated to dryness
  7. additionWater (30 cm3) was added
  8. additionthe solution was treated with acetone until complete precipitation
  9. filtrationThe product was collected by filtration
  10. customdried

Sources & evidence

ORD record
ord-b6acc349bec0426d94b45ef19fe9410c
Source dataset
uspto-grants-1983_12
Patent number
US04419352

Reaction notes

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