Thiophenol → HCID 135773207, compound

HRID 904701Notes

Reaction equation

HRID 904701 reaction equation
[CH:1]1[CH:6]=[CH:5][C:4]([SH:7])=[CH:3][CH:2]=1.[C:8]([C:11]1[CH:12]=[C:13]2[C:18](=[C:19]([CH2:22][CH2:23][CH3:24])[C:20]=1[OH:21])[N:17]=[C:16]([C:25]([O:27][CH3:28])=[O:26])[CH:15]=[C:14]2Cl)(=[O:10])[CH3:9]>CO>[C:8]([C:11]1[CH:12]=[C:13]2[C:18](=[C:19]([CH2:22][CH2:23][CH3:24])[C:20]=1[OH:21])[N:17]=[C:16]([C:25]([O:27][CH3:28])=[O:26])[CH:15]=[C:14]2[S:7][C:4]1[CH:5]=[CH:6][CH:1]=[CH:2][CH:3]=1)(=[O:10])[CH3:9]

Participants

4

Reactant 2

HCID 7969ThiophenolHCID 136035444HCID 136035444, compound

Product 1

HCID 135773207HCID 135773207, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Phenylthiol (1.87 g) was added to a stirred boiling solution of methyl 6-acetyl-4-chloro-7-hydroxy-8-propyl-quinoline-2-carboxylate (4.97 g) in dry methanol (600 ml) and the solution was boiled for 6 hours. The resulting suspension was cooled and the sub-title compound (2.2 g) filtered off and recrystallised from methanol as yellow needles m.p. 171°-2° C.

Workup

  1. temperatureThe resulting suspension was cooled
  2. filtrationthe sub-title compound (2.2 g) filtered off
  3. customrecrystallised from methanol as yellow needles m.p. 171°-2° C.

Sources & evidence

ORD record
ord-616ed5b1053544a18b80153188893a8b
Source dataset
uspto-grants-1983_12
Patent number
US04419352

Reaction notes

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