Water → HCID 13543928, compound

HRID 904708Notes

Reaction equation

HRID 904708 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH2:22][CH2:23][CH3:24])[C:8]3[O:15][C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:13][C:12](=S)[C:9]=3[CH:10]=2)[N:5]=[C:4]([C:25]([O:27][CH3:28])=[O:26])[CH:3]=1.[OH2:29].CI>CC(C)=O>[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH2:22][CH2:23][CH3:24])[C:8]3[O:15][C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:13][C:12](=[O:29])[C:9]=3[CH:10]=2)[N:5]=[C:4]([C:25]([O:27][CH3:28])=[O:26])[CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 6328Methyl iodideHCID 20478390Ethyl 6-chloro-8-methoxycarbonyl-10-propyl-4-thioxo-4H-pyrano[3,2-g]quinoline-2-carboxylate

Product 1

HCID 13543928HCID 13543928, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Ethyl 6-chloro-8-methoxycarbonyl-10-propyl-4-thioxo-4H-pyrano[3,2-g]quinoline-2-carboxylate (0.030 g) in acetone (10 ml) containing water (0.2 ml) and methyliodide (0.1 ml) was stirred in the dark at room temperature for 2 days. Concentration of the reaction mixture gave a light buff solid, which was recrystallised from ethanol to give the title compound (0.015 g), mp 176°-179°.

Workup

  1. customConcentration of the reaction mixture gave a light buff solid, which
  2. customwas recrystallised from ethanol

Sources & evidence

ORD record
ord-ea1d25777f054560a13279f0275bf02f
Source dataset
uspto-grants-1983_12
Patent number
US04419352

Reaction notes

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