反应详情

A solution of 36.5 g of 2-(methylsulfonyl)benzyl bromide and 11.4 g of thiourea in 500 ml absolute ethanol was stirred at reflux temperature for 11/2 hours and then allowed to cool to room temperature. Upon standing, the solution yielded white feather-like crystals which were collected by filtration, washed with cold 1-chlorobutane, and dried in vacuo. The yield of 2-(methylsulfonyl)phenylmethyl carbamimidothioate hydrobromide, m.p. 203°-206° C., was 36.3 g.

1. temperatureat reflux temperature for 11/2 hours
2. customthe solution yielded white feather-like crystals which
3. filtrationwere collected by filtration
4. washwashed with cold 1-chlorobutane
5. customdried in vacuo