2-Amino-4,6-dimethoxypyrimidine → HCID 13282686, compound

HRID 904774Notes

Reaction equation

HRID 904774 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][S:12]([N:15]=[C:16]=[O:17])(=[O:14])=[O:13])(=[O:4])=[O:3].[CH3:18][O:19][C:20]1[CH:25]=[C:24]([O:26][CH3:27])[N:23]=[C:22]([NH2:28])[N:21]=1>ClCCl>[CH3:18][O:19][C:20]1[CH:25]=[C:24]([O:26][CH3:27])[N:23]=[C:22]([NH:28][C:16]([NH:15][S:12]([CH2:11][C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:2]([CH3:1])(=[O:3])=[O:4])(=[O:13])=[O:14])=[O:17])[N:21]=1

Participants

4

Reactant 2

HCID 1189462-Amino-4,6-dimethoxypyrimidineHCID 13282662HCID 13282662, compound

Product 1

HCID 13282686HCID 13282686, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3.0 g of the product from Example 10 in 30 ml dry dichloromethane was added 1.2 g of 4,6-dimethoxy-2-aminopyrimidine and the yellow homogeneous solution was stirred at room temperature overnight. The desired product, which had precipitated, was collected by filtration, washed with 1-chlorobutane, and dried in vacuo. The yield of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(methylsulfonyl)phenylmethanesulfonamide, m.p. 180°-182° C., was 2.4 g of white solid.

Workup

  1. customThe desired product, which had precipitated
  2. filtrationwas collected by filtration
  3. washwashed with 1-chlorobutane
  4. customdried in vacuo

Sources & evidence

ORD record
ord-476528ebe05143d8838fbcdfcd43058e
Source dataset
uspto-grants-1983_12
Patent number
US04420325

Reaction notes

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