L-(-)-Ornithine → HCID 131713240, compound

Participants

Reaction Steps

To an aqueous solution of free L-ornithine (400 ml, content of L-ornithine: 1.167 mole) is gradually added with stirring L-malic acid (78.29 g, 1/2 mole per 1 mole of L-ornithine). The reaction mixture is concentrated under reduced pressure until the total amount of the mixture becomes 500 g. To the resulting aqueous solution is added with stirring methanol (300 ml), by which a little amount of crystals is precipitated. To the mixture is further added methanol (each 100 ml) five times at an interval of 10 minutes. The mixture is allowed to stand at room temperature to crystallize out the salt well, and the precipitated crystals are separated by filtration. The crystals are washed with a 90% aqueous methanol solution and are air-dried at 60° C. overnight to give neutral L-ornithine L-malate dihydrate (233.5 g, yield: 92.1%) as colorless platy crystal. m.p. 136° C. (decomp.)

Provenance & Evidence