L-(-)-Ornithine → HCID 131713240, compound

Participants

Reaction Steps

To an aqueous solution of free L-ornithine [100 ml, content of L-ornithine: 20.23 g(0.15312 mole)] is gradually added with stirring L-malic acid (8.21 g, 0.8 mole per 2 moles of L-ornithine). The reaction mixture is concentrated under reduced pressured until the total amount of the mixture becomes 60 g. To the resulting aqueous solution is added with stirring methanol (30 ml), by which a little amount of crystals is precipitated. After 30 minutes, methanol (20 ml) is further added thereto at room temperature. The resulting mixture is treated in the same manner as described in Example 1 to give neutral L-ornithine L-malate dihydrate (25.0 g, yield: 93.95%) as colorless platy crystal.

Provenance & Evidence