L-Lysine → HCID 131713241, compound

Participants

Reaction Steps

To an aqueous solution (200 ml) of free L-lysine (content of L-lysine: 0.558 mole) is gradually added with stirring L-malic acid (36.51 g, 1/2 mole per 1 mole of L-lysine). After the reaction, the reaction mixture is concentrated under reduced pressure until the total amount of the mixture becomes 214 ml. To the resulting aqueous solution is added with stirring methanol (250 ml) to precipitate crystals. To the mixture is further added methanol (each 55 ml) for ten times at an interval of 30 minutes in order to precipitate crystals well. The precipitated crystals are collected by filtration and are treated in the same manner as described in Example 5 to give neutral L-lysine L-malate monohydrate (115.3 g, yield: 95%) as colorless needle or prismatic crystals.

Provenance & Evidence