反应详情

温度

-78 °C

A solution of 50 ml. of tetrahydrofuran containing 7.33 ml. of bistrimethylsilylacetamide (30 millimoles) and 18.75 ml. of a 1.6 Molar solution of n-butyl lithium (30 millimoles) was stirred at -78° C. for ten minutes. A solution of 1.03 g. (3 millimoles) of 1-isopropylsulfonyl-2-amino-6-benzoylbenzimidazole in 100 ml. of tetrahydrofuran was then added to the cold reaction mixture dropwise over one hour. The temperature of the reaction mixture was maintained at -78° C. throughout the addition, and the reaction mixture was stirred for four hours at -78° C. following complete addition of the benzoylbenzimidazole. The reaction mixture next was diluted with 75 ml. of water and 33 ml. of 1 N hydrochloric acid. The organic layer was separated and the aqueous acid layer was extracted several times with ethyl acetate. The organic layer and extracts were combined, washed with fresh water and dried. Removal of the solvent by evaporation under reduced pressure afforded a white solid product. Purification of the product by chromatography over silica gel afforded 1-isopropylsulfonyl-2-amino-6-(α-hydroxy-α-aminocarbonylmethylbenzyl)benzimidazole.

1. additionThe reaction mixture next was diluted with 75 ml
2. customThe organic layer was separated
3. extractionthe aqueous acid layer was extracted several times with ethyl acetate
4. washwashed with fresh water
5. customdried
6. customRemoval of the solvent
7. customby evaporation under reduced pressure
8. customafforded a white solid product
9. customPurification of the product by chromatography over silica gel