Chlorosuccinimide → HCID 54170662, compound

Participants

Reaction Steps

A solution of 500 mg. of 1-(thiazin-2-yl)-2-amino-6-(α-methylenebenzyl)benzimidazole in 50 ml. of tetrahydrofuran containing 250 mg. of N-chlorosuccinimide was stirred at room temperature for sixteen hours. The reaction mixture was filtered, and the filtrate was diluted with water and then concentrated to a volume of about 25 ml. The precipitate which formed was collected by filtration, dried, and identified as 140 mg. of 1-(thiazin-2-yl)-2-amino-6-(α-chloromethylenebenzyl)benzimidazole.

Provenance & Evidence