HCID 13277355, compound → HCID 13277359, compound

Participants

Reaction Steps

A solution of 1-(2-diisopropylaminoethyl)-5,7-dimethyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-2-one (3.5 g, 11.1 mmol) in methylene chloride (100 ml) containing activated manganese dioxide (9.0 g) is heated at reflux for 16 hours. The solution is filtered hot to remove the manganese dioxide and the manganese dioxide is extracted twice with hot chloroform. The organic extracts are combined, dried and evaporated to give 3.6 g of crude product which is crystallized from cyclohexane to give 2.0 g of pure title product; m.p.: 148°-150° C.

Provenance & Evidence