反应详情

A solution of 1-(2-dimethylaminoethyl)-5,7-dimethyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-2-one (5.0 g, 20 mmol) in chloroform (150 ml) containing activated manganese dioxide (15 g) is refluxed for 15 hours. The reaction mixture is filtered hot and the collected manganese dioxide re-extracted with hot chloroform. The combined organic extracts are evaporated and the residue crystallized from cyclohexane to yield 2.4 g of pure title product; m.p.: 137°-139° C.

1. temperatureis refluxed for 15 hours
2. filtrationThe reaction mixture is filtered hot
3. extractionthe collected manganese dioxide re-extracted with hot chloroform
4. customThe combined organic extracts are evaporated
5. customthe residue crystallized from cyclohexane