(2-{[2-(Dimethylamino)ethyl]amino}-4,6-dimethylpyridin-3-yl)methanol → HCID 20477991, compound

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Reaction Steps

A solution of crude 2-(2-dimethylaminoethylamino)-3-hydroxymethyl-4,6-dimethylpyridine (15.0 g, 67 mmol) in methylene chloride (300 ml) containing a suspension of activated manganese dioxide (35 g) is refluxed for 5 hours. The solution is filtered hot and the manganese dioxide re-extracted with hot methylene chloride. The combined extracts are filtered through charcoal and evaporated to give 12.0 g of crude title D product.

Provenance & Evidence