HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(6-Methoxy-2-naphthalenyl)-3-buten-2-one → Nabumetone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(6-Methoxy-2-naphthalenyl)-3-buten-2-one | HCID 53409926 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Nabumetone | HCID 4409 | 69.7% |
Reaction Steps
4-(6-Methoxy-2-naphthyl)-3-butene-2-one (32 g) in ethyl acetate (500 ml) was shaken at room temperature over 10% Pd/C (3 g) under atmospheric pressure hydrogen until no further uptake of hydrogen occurred to yield 4-(6-methoxy-2-naphthyl)butan-2-one (22.5 g), mp. 78.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04420639 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-2d41f0e4ef95449290297d6d08cfd8ca |
| Source note | uspto-grants-1983_12 |