L-Isoleucine → HCID 22824828, compound

HRID 904945Notes

Reaction equation

HRID 904945 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4].[ClH:10].[CH:11](O)([CH3:13])[CH3:12].N[C@H](C(O)=O)CCC(=O)O.N[C@H](C(O)=O)CCCNC(=N)N>>[ClH:10].[CH:11]([O:8][C:7](=[O:9])[C@H:2]([C@H:3]([CH2:5][CH3:6])[CH3:4])[NH2:1])([CH3:13])[CH3:12]

Participants

5

Reactant 4

HCID 6306L-Isoleucine2×HCID 33032L-Glutamic AcidHCID 21912024Isopropanol hydrochlorideHCID 178418600HCID 178418600, compound

Product 1

HCID 22824828HCID 22824828, compound

Procedure

Isoleucine isopropyl ester-hydrochloride is prepared in a known manner from isoleucine and HCl/isopropanol. 2.1 g of this compound are reacted analogously to Example 5 (C) with 14.4 g of Adoc-Arg(Adoc)2 -Arg(Adoc)2 -Glu(OBut)-OH.2H2O and the product is worked up. Yield 6.2 g. Aminoacid analysis: Glu 1.00, Ile 0.95 and Arg 2.06.

Sources & evidence

ORD record
ord-5836e49630c64daebb919cf83a4de2f2
Source dataset
uspto-grants-1983_12
Patent number
US04420424

Reaction notes

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