HCID 178476672, compound → HCID 178476675, compound

Participants

Reaction Steps

2 g (2.2 mmoles) of Z-D-Lys-Arg-Glu-Val-Tyr-OMe acetate are subjected to catalytic hydrogenation in 90 percent acetic acid and the product is worked up analogously to Example 25 I. Yield 1.8 g (98%). 800 mg are purified further by being chromatographed on a hydroxypropylated, crosslinked dextran gel (approx. 120 g, column: 90×2.5 cm) in 90 percent strength methanol. Yield 500 mg.

Provenance & Evidence