HCID 13187608, compound → HCID 13187609, compound

Participants

Reaction Steps

2.0 g of 4-(4-benzoylbutyl)-1-(cyanomethylamino)-piperazine dihydrochloride was dissolved in 22 ml of water, and while the solution was cooled to below 5° C., an aqueous solution containing 1.0 g of sodium nitrite was added over the course of 10 minutes. The reaction was carried out at this temperature for 2 hours. The reaction mixture was extracted with chloroform. The extract was washed with water and dried, and the chloroform was distilled off to give 4-(4-benzoylbutyl)-1-(N-nitrosocyanomethylamino)-piperazine.

Provenance & Evidence