HCID 13091805, compound → HCID 13091807, compound

HRID 905038Notes

Reaction equation

HRID 905038 reaction equation
[BrH:1].[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2(O)[CH2:13][S:12][C:11](=[N:14][C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=3)[N:10]2[CH3:22])=[CH:5][C:4]=1[S:24](=[O:29])(=[O:28])[N:25]([CH3:27])[CH3:26]>C(O)(=O)C>[BrH:1].[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]([CH3:22])[C:11](=[N:14][C:15]3[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=3)[S:12][CH:13]=2)=[CH:5][C:4]=1[S:24](=[O:29])(=[O:28])[N:25]([CH3:26])[CH3:27]

Participants

3

Reactant 1

HCID 13091805HCID 13091805, compound

Product 1

HCID 13091807HCID 13091807, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

5.23 g (0.01 mole) of 4-(4-chloro-3-dimethylsulfamoylphenyl)-3-methyl-2-(4-hydroxyphenylimino)-thiazolidin-4-ol hydrobromide in 70 ml of glacial acetic acid are heated in the course of 20 min. to boiling. After cooling, the crystallization is completed by addition of about 150 ml of diisopropyl ether, the mixture is stirred for a further hour at room temperature and filtered. Colorless crystals, m.p. 275°-279° C. (decomp.).

Workup

  1. temperatureAfter cooling
  2. customthe crystallization
  3. additionis completed by addition of about 150 ml of diisopropyl ether
  4. filtrationfiltered

Sources & evidence

ORD record
ord-392b2e83494e4f9fa320debac90ab00e
Source dataset
uspto-grants-1983_12
Patent number
US04421757

Reaction notes

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