Hydrochloric Acid → HCID 13091806, compound

Participants

Reaction Steps

A suspension of 1.7 g of 4-(4-chloro-3-dimethylsulfamoylphenyl)-2-(4-acetoxyphenylimino)-3-methyl-4-thiazoline (Example 8) in 30 ml of ethanol and 20 ml of water is brought to pH 11-12 with 2 N caustic soda and stirred at room temperature for 3 hours. After neutralization with 2 N hydrochloric acid, and repeated extraction with methyl acetate, the organic phases are dried, evaporated and the residue recrystallized from ethyl acetate/ethanol. Beige-colored crystals of m.p. 188°-190° C., identical with the product obtained by the method (a)-(c) by thin layer comparison.

Provenance & Evidence