Acetic Anhydride → HCID 20476832, compound

HRID 905041Notes

Reaction equation

HRID 905041 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH3:21])[C:10](=[N:13][C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)[S:11][CH:12]=2)=[CH:4][C:3]=1[S:22](=[O:27])(=[O:26])[N:23]([CH3:25])[CH3:24].[C:28](OC(=O)C)(=[O:30])[CH3:29]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH3:21])[C:10](=[N:13][C:14]3[CH:15]=[CH:16][C:17]([O:20][C:28](=[O:30])[CH3:29])=[CH:18][CH:19]=3)[S:11][CH:12]=2)=[CH:4][C:3]=1[S:22](=[O:27])(=[O:26])[N:23]([CH3:24])[CH3:25]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 13091806HCID 13091806, compound

Product 1

HCID 20476832HCID 20476832, compound

Conditions

Temperature
120 °C

Procedure

2.1 g (5 mmoles) of 4-(4-chloro-3-dimethylsulfamoylphenyl)-2-(4-hydroxyphenylimino)-3-methyl-4-thiazoline (Example 2) are suspended in 25 ml of acetic anhydride and the yellow solution which results on warming, is stirred for 1 hour at 120° C. After distilling off the acetic anhydride in vacuo, the solid residue is recrystallized from isopropanol. Colorless crystals of m.p. 173°-174° C.

Workup

  1. customthe yellow solution which results
  2. temperatureon warming
  3. distillationAfter distilling off the acetic anhydride in vacuo
  4. customthe solid residue is recrystallized from isopropanol

Sources & evidence

ORD record
ord-8e405a98c8da47ebad4e6a15074089b9
Source dataset
uspto-grants-1983_12
Patent number
US04421757

Reaction notes

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