HCID 13091592, compound → HCID 13091805, compound

Participants

Reaction Steps

6.8 g (0.02 mole) of 2-bromo-4'-chloro-3'-dimethylsulfamoylacetophenone are dissolved in 60 ml of acetone or 150 ml of ethanol or 50 ml of ethyl acetate and, after addition of a solution of 3.7 g (0.022 mole) of 1-(4-hydroxyphenyl)-3-methyl-thiourea in 60 ml of acetone or 50 ml of ethanol or 100 ml of ethyl acetate, the solution is stirred at room temperature for 1 to 4 hours, the crystals are filtered off and, after washing with a little acetone and ether, dried in a cool stream of air or in vacuo over paraffin shavings. Colorless crystals, m.p. 255°-264° C. with decomposition, by slow heating; m.p. 178°-180° C., by rapid heating.

Provenance & Evidence