HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl 2-bromo-4-fluoro-3-(3-methoxyphenyl)but-2-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | HCID 13276222 | HCID 13276222 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Ethyl 2-bromo-4-fluoro-3-(3-methoxyphenyl)but-2-enoate | HCID 54176609 | 102% |
Reaction Steps
Piperidine (0.22 ml) is added to a solution of ethyl 2,3-dibromo-3-(3'-methoxyphenyl)-4-fluorobutyrate (0.80 g) in ether (10 ml). The reaction mixture is stirred at room temperature for 3 hours and water is added. Ether extraction gives essentially pure ethyl 2-bromo-3-(3'-methoxyphenyl)-4-fluoro-2-butenoate (0.65 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04421767 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-992072f89bcb4155a85e80bada20da26 |
| Source note | uspto-grants-1983_12 |