Sodium Iodide → HCID 54388384, compound

Participants

Reaction Steps

97.5 mg of 1,2,4-triazole and 62 mg of 55% sodium hydride, 142 mg of sodium iodide, 533 mg of trans-6-[α-(2,4-dichlorobenzyl)-4-methoxybenzyloxy]-2-tosyloxymethyltetrahydropyran and 6 ml of dimethylformamide were reacted and treated essentially as described in Example 3(b) and then the product was purified by column chromatography through silica gel eluted with a 1:2 by volume mixture of benzene and ethyl acetate, to give 244 mg of an isomer of lesser polarity, 109 mg of an isomer of greater polarity and 52 mg of a mixture of the two isomers (in which the ratio of the isomers of lesser to greater polarity was about 2:1).

Provenance & Evidence