Phosgene → HCID 20477495, compound

HRID 905108Notes

Reaction equation

HRID 905108 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH2:7][CH2:6][C:5]2=[O:12].[C:13](Cl)([Cl:15])=[O:14]>O1CCOCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([C:13]([Cl:15])=[O:14])[CH2:7][CH2:6][C:5]2=[O:12]

Participants

4

Reactant 2

HCID 6371PhosgeneHCID 7594476-BROMO-2,3-DIHYDROQUINOLIN-4(1H)-ONE

Product 1

HCID 20477495HCID 20477495, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

45.2 Parts of 6-bromo-4-oxo-1,2,3,4-tetrahydroquinoline and 200 parts of dioxane were mixed, and 39.4 parts of phosgene was introduced to the stirred mixture while the temperature was maintained at 20°-25° C. over about 30 minutes. After the introduction, the reaction was effected at 40°-45° C. for 2.5 hours, and thereafter the mixture was treated as in Example 37 (a) to obtain 55.9 parts of 6-bromo-4-oxo-1-chloroformyl-1,2,3,4-tetrahydroquinoline.

Workup

  1. temperaturewas maintained at 20°-25° C. over about 30 minutes

Sources & evidence

ORD record
ord-8b0a02192f7b4aa8a270586723668643
Source dataset
uspto-grants-1983_12
Patent number
US04421919

Reaction notes

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