N-Methylaniline → HCID 20477404, compound

Participants

Reaction Steps

N-methylaniline (15.1 g), diethyl bromomalonate (16.9 g) and dry benzene (90 ml) were mixed and heated under reflux for 16 hours with stirring. The reaction mixture was washed, dried and concentrated by the same procedure as in Example 2, (1). The residue was purified by silica gel column chromatography using benzene/hexane (2:1) as an eluent to give 10.2 g (yield 54%) of diethyl N-methylanilinomalonate having the following NMR data.

Provenance & Evidence