反应详情

A mixture of 1,2-divinylcyclododecan-1-ol (0.125 g, 5.10-4 mol), lithium trifluoromethanesulphonate (0.080 g) and mercuric trifluoroacetate (0.045 g) in methylene chloride (5 cc) is kept at a temperature of the order of 20° C. for 20 minutes. The reaction mixture is washed with a saturated aqueous solution of sodium bicarbonate (3×10 cc) and then extracted with methylene chloride (3×10 cc). The organic extracts are dried over magnesium sulphate. After filtration and concentration to dryness under reduced pressure (20 mm Hg; 2.7 kPa), cyclohexadec-5-en-1-one (0.085 g) is obtained with a yield of 69%.

1. washThe reaction mixture is washed with a saturated aqueous solution of sodium bicarbonate (3×10 cc)
2. extractionextracted with methylene chloride (3×10 cc)
3. dry with materialThe organic extracts are dried over magnesium sulphate
4. filtrationAfter filtration and concentration to dryness under reduced pressure (20 mm Hg; 2.7 kPa)