Hydrochloric Acid → HCID 20568371, compound

Participants

Reaction Steps

A mixture of 3.8 g (16.9 mmol) of the propionitrile (5) prepared according to the procedure of Example 11 (melting point 69°-72° C.), 3.5 g (87 mmol) of NaOH, 25 ml of H2O and 25 ml of CH3OH was allowed to reflux for 16 hours. The resulting clear, colorless solution was acidified with HCl and extracted with Et2O. The resulting Et2O solution was dried and concentrated to yield 4.0 g (98%) of the propionic acid (6) as a colorless solid having a melting point of 109°-113° C. According to the Merck Index, Ninth Edition, 1976, pure flurbiprofen melts at 113°-114° C.

Provenance & Evidence