Tofisopam → HCID 13500543, compound

Participants

Reaction Steps

A 70% benzene solution of 90 ml (0.6 moles) of NaAlH2 (OCH2CH2OCH3)2 is diluted with 90 ml of benzene. The solution thus-obtained is added, within 20 minutes, under stirring, to a solution of 114.6 g (0.3 moles) of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine in 1500 ml of benzene. The inner temperature rises to 33° to 35° C. Then the reaction mixture is heated to boiling, within 30 minutes (the gas evolution ceases), recooled to 20° C., and 450 ml of a 20% sodium hydroxide solution (or, in case of compounds containing phenolic hydroxy groups, an aqueous sodium carbonate solution) are dropped to it. A two-phase light yellowish mixture is obtained.

Provenance & Evidence