Ammonium Hydroxide → Glutarimide, 3-methyl-3-propyl-

Participants

Reaction Steps

A 10 g (0.06 mole) quantity of the anhydride prepared in Example 1 was added in small portions to 120 mL conc. NH4OH. After the addition was completed, the mixture was heated to a gentle reflux and stirred for 4 hr. Upon cooling the reaction mixture, a yellow oil precipitated which solidified to a glass. Crystallization of the glass from isopropyl alcohol gave 8 g (80%) of crude product, m.p. 110°-120° C. (literature m.p. 115°-116°, Cf: N. S. Benica and C. O. Wilson, J. Am. Pharm. Assoc., 39, page 451-454 (1950)).

Provenance & Evidence