77528-46-2 → 4,5,6,7-Tetrahydro-4-benzothiazolemethanol

Participants

Reaction Steps

To a solution of 1.14 g (30 mmoles) of AlLiH4 in 50 ml anhydrous tetrahydrofuran, cooled to -20° C. and maintained at that temperature, are slowly added 6.66 g (30 mmoles) of the above derivative (III) dissolved in 30 ml anhydrous THF. After 30 minutes at -20° C., excess AlLiH4 is destroyed by addition of isopropanol at -20° C. followed by 5 ml saturated aqueous sodium chloride, and is then stirred for 2 hrs. The resulting precipitate is filtered off and washed with ethyl acetate; the filtrate is evaporated and the oily residue is taken up in the hot with hexane; product (IV) crystallizes on cooling. Yield: 70%. M.p.=74°-75° C.

Provenance & Evidence