HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → 2-Chloromethylthio-5-chloropyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | 5-Chloro-2-(methylthio)pyrimidine | HCID 4737063 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Chloromethylthio-5-chloropyrimidine | HCID 13435135 | 82% |
Reaction Steps
2-Methylthio-5-chloropyrimidine (75 mmol) and sulfuryl chloride (104 mmol) were heated together in refluxing dichloromethane (100 ml) for 3 h. Evaporation of the mixture left a solid which was recrystallized from ethanol; yield 82%, m.p. 78° C. 1H NMR (CDCl3): 5.20 (SCH2), 8.54 (H-4, H-6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04423047 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-c3f5d4f3ef07438dbbc7a0e9cd2071ca |
| Source note | uspto-grants-1983_12 |