Propargyl bromide → HCID 12958928, compound

Participants

Reaction Steps

A mixture of 5-chloropyrimidine-2-thione (5 mmol) and triethylamine (5 mmol) was stirred together in dichloromethane (40 ml) for 5 min before propargyl bromide (6 mmol) was added. The mixture was stirred at room temperature for 1 h before the solvent was evaporated. The residue was triturated with water (20 ml), and the solid recrystallized from methanol; yield 87%, m.p. 66° C. 1H NMR (CDCl3): δ2.16 (HC≡, t, J 2 Hz), 3.88 (CH2, d, J 2 Hz), 8.80 (H-4, H-6). IR (KBr): 3300 Cm-1 (HC≡).

Provenance & Evidence