Phenacyl bromide → HCID 20475753, compound

Participants

Reaction Steps

5-Bromopyrimidine-2-thione (10.5 mmol) was added to a solution of triethylamine (11.6 mmol) in EtOH (130 ml) and the mixture stirred for 15 min before addition of phenacyl bromide (10.5 mmol). The reaction mixture was stirred for 1 h before the solvent was removed at reduced pressure, the residue extracted with chloroform and the chloroform solution chromatographed on alumina (100 g, activity I); yield 71%, m.p. 107°-109° C. (iPrOH). 1H NMR (CDCl3): δ4.60 (CH2), 7.5-8.0 (Ph), 8.46 (H-4, H-6).

Provenance & Evidence