HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenol → 2-(4-Chlorophenoxymethyl)thio-5-chloropyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenol | HCID 4684 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | 2-(Iodomethyl)thio-5-chloropyrimidine | HCID 13435136 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(4-Chlorophenoxymethyl)thio-5-chloropyrimidine | HCID 20475741 | 64% |
Reaction Steps
2-(Iodomethyl)thio-5-chloropyrimidine was added to a solution of p-chlorophenol (5.5 mmol) and 0.138 M NaOEt in ethanol (40 ml) and the mixture stirred at room temperature overnight. The solvent was distilled off and the mixture worked up as above; yield 64%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04423047 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-e01055291f9f47b9b210f83ac20327af |
| Source note | uspto-grants-1983_12 |