HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Thiophenemethanol → HCID 20475734, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Thiophenemethanol | HCID 69467 | — |
| Reactant | Bromoacetyl chloride | HCID 89602 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 20475734 | HCID 20475734 | 48% |
Reaction Steps
A solution of bromoacetyl chloride (60 mmol) and 2-hydroxymethylthiophene (60 mmol) in benzene (100 ml) was heated under reflux for 90 min, the cold solution shaken with saturated NaHCO3 aq., the dried (MgSO4) solution evaporated and the residue fractionally distilled; yield 48%, b.p. 96° C./0.05 mmHg. 1H NMR (CDCl3) δ3.80 (CH2), 5.30 (OCH2), 7.00 and 7.26 (thiophene).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04423047 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-3a1c9aa8b1ac44e1a2c9c5475ccd83ad |
| Source note | uspto-grants-1983_12 |