HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 5-Bromo-2-[(phenylmethyl)sulfinyl]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 2-(Benzylsulfanyl)-5-bromopyrimidine | HCID 20475712 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Bromo-2-[(phenylmethyl)sulfinyl]pyrimidine | HCID 20475718 | 91% |
Reaction Steps
The oxidation of 2-benzylthio-5-bromopyrimidine was carried out using one molar equivalent of 85% m-chloroperbenzoic acid in dichloromethane, initially at -10° C. and then at 0° C., as described in Example 40 above; yield 91%, m.p. 101° C. (iPrOH). 1H NMR (CDCl3); δ4.26 and 4.31 (CH2), 7.16 (Ph), 8.80 (H-4, H-6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04423047 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-494365b70ba743d1b0ac86136f4fdd02 |
| Source note | uspto-grants-1983_12 |