Hydrogen Peroxide → HCID 12958933, compound

Participants

Reaction Steps

A mixture of selenium dioxide (4 mmol) and 35% H2O2 (4 mmol) in water (2.5 ml) was added to a solution of 2-propargylthio-5-chloropyrimidine in methanol (10 ml). The mixture was stirred at room temperature for 18 h before water (50 ml), saturated with NaCl, was added and the mixture extracted with chloroform (3×20 ml). The dried (MgSO4) chloroform solution was evaporated and the residue recrystallized from chloroform: pet. ether; yield 63%, m.p. 92° C. 1H NMR (CDCl3): δ2.28 (HC≡t, J 2 Hz), 3.87 and 4.09 (CH2J 15 Hz), 8.85 (H-4, H-6), IR (KBr): 3235 (CH≡), 2110 and 2100 (--C≡C--). MS [70 eV; m/e (% rel. int)]: 200 (13, M) 199 (19), 173 (33), 171 (100), 146 (25), 114 (30), 113 (31), 111 (47).

Provenance & Evidence