Hydrogen Peroxide → HCID 20475751, compound

Participants

Reaction Steps

A mixture of 35% H2O2 (1.9 mmol) and SeO2 (1.9 mmol) in water (1.5 ml H2O) was added to a solution of 2-(2,3-epoxypropyl)thio-5-chloropyrimidine (1.9 mmol) in methanol (7 ml). The mixture was stirred at room temperature for 4 h before saturated NaCl aq. (30 ml) was added and the mixture extracted with chloroform (3×15 ml). The dried (MgSO4) chloroform solution was evaporated and the residue purified by preparative TLC on silica gel using CHCl3 : EtOH (95:5); yield 24%, m.p. 92° C. 1H NMR (CDCl3): δ2.4-3.6 (5H, m), 8.84 (H-4, H-6). IR (KBr): 1050 cm-1 (SO).

Provenance & Evidence