HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenol → 4-Chlorophenyl 4-(8-cyclohexyloctylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenol | HCID 4684 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | p-(8-Cyclohexyloctyl)aminobenzoyl chloride hydrochloride | HCID 20475769 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Chlorophenyl 4-(8-cyclohexyloctylamino)benzoate | HCID 20475836 | — |
Reaction Steps
To a solution of 6.4 g. 4-chlorophenol and 7.6 g. triethylamine in 500 ml. methylene chloride is added 10.4 g. 4-(8-cyclohexyloctylamino)benzoyl chloride hydrochloride in 250 ml. methylene chloride. After four hours at reflux, the solution is cooled, washed with water and dilute phosphoric acid, and dried. After passing the solution through a column of alumina, the solvent is evaporated an the residue is crystallized from diisopropyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04423051 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-e23027eb14544ef0a5f2b75fae7a2471 |
| Source note | uspto-grants-1983_12 |