HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 2-Tetrahydropyranyl 4-(8-cyclohexyloctylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | 4-(8-Cyclohexyloctylamino)benzoic acid | HCID 20475772 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Tetrahydropyranyl 4-(8-cyclohexyloctylamino)benzoate | HCID 20475834 | — |
Reaction Steps
A mixture of 7 g. 4-(8-cyclohexyloctylamino)benzoic acid, 2 g. 2,3-dihydropyran and 100 mg. anhydrous p-toluenesulfonic acid in 50 ml. toluene is stirred at room temperature for 20 hours. The solution is washed with saturated sodium bicarbonate, dried, and condensed. The residue is crystallized from methylcyclohexane to white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04423051 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-82e37ac1a3fc4c2c9dac6c33089a34dd |
| Source note | uspto-grants-1983_12 |