Butyric Acid → HCID 20446789, compound

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A mixture of 2-{N-benzyl-N-[2-(2-phenylacetamido)ethyl]amino}-3',4'-dihydroxyacetophenone hydrobromide (1.0 g.) and butyric acid (6 ml.) was saturated at room temperature with gaseous hydrogen chloride during 3 minutes. Butyryl chloride (6 ml.) was then added and the mixture was stirred at 90°-95° C. for 1.5 hours, giving a clear solution after about 5 minutes. The solution was then concentrated to half volume by evaporation under reduced pressure and the residue was diluted with ether (25 ml.) to give 2-{N-benzyl-N-[2-(2-phenylacetamido)ethyl]amino}-3',4'-bis(butyryloxy)acetophenone hydrochloride as a solid precipitate (0.65 g.), m.p. 115°-117° C.

Provenance & Evidence