HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (ethoxymethylene)malonate → 2-(2,2-Dicarbethoxyethenylamino)-4-ethylthiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 4-Ethyl-1,3-thiazol-2-amine | HCID 12378205 | — |
| Product | 2-(2,2-Dicarbethoxyethenylamino)-4-ethylthiazole | HCID 13253362 | — |
Reaction Steps
2-Amino-4-ethylthiazole (20.5 g., 0.16 mole) and diethyl ethoxymethylenemalonate (35 g., 0.17 mole) were combined and heated on a steam bath for 2 hours. 2-(2,2-dicarbethoxyethenylamino)-4-ethylthiazole was obtained as an oil on cooling, and was used directly in the next step. (Rf 0.75 on silica gel thin layer chromatography with chloroform/1% ethanol as eluant.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04423048 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-9e6ef2e607ad47f19857d2661e8f3992 |
| Source note | uspto-grants-1983_12 |