1,2-Dichloro-3-nitro-5-(trifluoromethyl)benzene → 2,3-Dichloro-5-(trifluoromethyl)aniline

Participants

Reaction Steps

500 ml. of an ethanolic solution containing 3,4-dichloro-5-nitro-α,α,α-trifluorotoluene (188 g. 0.72 mol), and platinum oxide (Adam's catalyst) (0.2 g.) is reduced at room temperature in a low pressure hydrogenation apparatus to give 5-Amino-3,4-dichloro-α,α,α-trifluorotoluene (129.9 g. 78%) b.p. 65°-70° C./1-2mm.

Provenance & Evidence